High-dose turmeric supplements exceeding 2500 mg daily can cause liver damage in humans.

Caveats

• The 2,500 mg figure is not an established regulatory or clinical hepatotoxic threshold — it appears derived from individual case reports, not dose-response data. Authoritative sources cite safe tolerability at far higher doses for most people.
• Turmeric-related liver injury is idiosyncratic (immune-mediated, linked to HLA-B*35:01 genetic susceptibility), meaning it can occur at doses below 2,500 mg in susceptible individuals and is not triggered by crossing a specific dose threshold.
• Piperine (black pepper extract), commonly added to turmeric supplements, can increase curcumin bioavailability up to 20-fold, making the actual systemic exposure — not the labeled dose — the more relevant risk variable.