The Short Version
Multiple longitudinal studies, pharmacovigilance cohorts, case reports, and fluoxetine’s own prescribing information document changes in white-cell counts, occasional thrombocytopenia, and other hematologic shifts after SSRI use. These findings confirm that selective serotonin reuptake inhibitors, including fluoxetine, can influence blood-count parameters, even though the effects are generally small or rare and not uniform across all patients.