The Short Version
This claim is not supported by the weight of evidence. Multiple controlled studies and major medical organizations — including the AAAAI, American Lung Association, and WHO-aligned guidance — consistently find that wearing masks, even for extended periods, does not cause clinically meaningful drops in blood oxygen levels. A few studies detected tiny, statistically significant SpO2 changes in narrow occupational settings, but these remained within normal physiological ranges and do not constitute harmful oxygen reduction for typical wearers.