The Short Version
The claim is well-supported by multiple peer-reviewed biomedical studies confirming that the adult human brain consumes approximately 20% of the body's total oxygen at rest. This is a widely accepted figure in neuroscience. Minor caveats: the figure applies specifically to adults in a resting/basal state, some sources cite a 15–20% range, and the proportion is significantly higher in young children. These are standard qualifications that don't undermine the claim's core accuracy.