Topic

LETM1

2 claims checked

SCIENCE May 30, 2026

LETM1 was first identified while mapping the Wolf–Hirschhorn syndrome 4p16.3 critical region.

Claim: Leucine zipper EF-hand-containing transmembrane protein 1 (LETM1) was initially identified through studies investigating the genetic basis of Wolf–Hirschhorn syndrome (WHS). NOT BS

SCIENCE May 13, 2026

LETM1 contributes proton-coupled mitochondrial Ca2+ transport alongside MCU and NCLX.

Claim: LETM1 is a proton-coupled mitochondrial calcium transport pathway that complements the mitochondrial calcium uniporter (MCU) and the sodium/calcium/lithium exchanger (NCLX) in controlling mitochondrial Ca2+ dynamics. HARDLY BS