The Short Version
The claim is mostly true but slightly imprecise. Peer-reviewed research consistently identifies caffeine — not coffee specifically — as the world's most widely consumed psychoactive substance. Coffee is caffeine's dominant delivery vehicle (~69% of global intake), but caffeine is also consumed through tea, energy drinks, and soft drinks. In regions like Asia and the UK, tea is the primary caffeine source. No study directly counts unique global coffee drinkers to compare against alcohol (2.4 billion users) or tobacco (1.14 billion). The claim is well-supported in spirit but oversimplifies the picture.