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Excess body fat is associated with lower testosterone levels in men.

The Claim

Men with excessive body fat mass tend to have insufficient androgen levels.

The Short Version

Men with excess body fat are more likely to have lower testosterone, particularly with greater visceral adiposity. Observational and genetic evidence supports the association and suggests that increased fat mass can contribute to reduced testosterone. However, lower total testosterone does not always mean clinically significant androgen deficiency because free testosterone may remain normal.

Caveats

  • Most available evidence measures testosterone, not the full range of androgens.
  • Obesity can reduce sex hormone-binding globulin and total testosterone while free testosterone remains normal.
  • Lower testosterone alone does not establish clinical hypogonadism; symptoms and repeat biochemical testing are required.

The Receipts

  1. The Impact of Visceral Adiposity on Testosterone Levels in ...

    pmc.ncbi.nlm.nih.gov

  2. Low Testosterone Concentrations in Men With Obesity - PMC

    pmc.ncbi.nlm.nih.gov

  3. Association between visceral adipose tissue and total testosterone among the United States male adults: a cross-sectional study | International Journal of Impotence Research

    preview-www.nature.com

  4. Percent body fat was negatively correlated with Testosterone ...

    pmc.ncbi.nlm.nih.gov

  5. European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

    doi.org

  6. Management of male obesity-related secondary hypogonadism: A clinical update

    pmc.ncbi.nlm.nih.gov

  7. Male Obesity-related Secondary Hypogonadism – Pathophysiology, Clinical Implications and Management

    pmc.ncbi.nlm.nih.gov

  8. Lowered testosterone in male obesity: mechanisms, morbidity and management - PMC

    pmc.ncbi.nlm.nih.gov

  9. Causal relationship between obesity and serum testosterone ...

    pmc.ncbi.nlm.nih.gov

  10. Lowered testosterone in male obesity: Mechanisms, morbidity and management

    ncbi.nlm.nih.gov

+ 28 more sources — see the full list on Lenz

Filed Under

Androgens

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