The Short Version
The claim that squats are categorically more effective than leg press for muscle hypertrophy is misleading. While one peer-reviewed study found squats superior in an 8-week protocol, the broader scientific evidence indicates that when training volume and intensity are matched, both exercises produce comparable overall muscle growth, with each favoring different muscle regions. Squats recruit more total muscle mass, but this does not automatically translate to greater hypertrophy in any specific muscle group. The blanket claim oversimplifies a nuanced, context-dependent reality.