The human enzyme CYP2C19 metabolizes about 10% of commonly prescribed medications, including some antidepressants, proton pump inhibitors, clopidogrel, and voriconazole.
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The Short Version
Reliable medical references support the statement that CYP2C19 is involved in metabolizing about 10% of commonly prescribed drugs. The cited examples—some antidepressants, proton pump inhibitors, clopidogrel, and voriconazole—are all well-established CYP2C19-related medications. The exact percentage can vary by source and definition, but that caveat does not change the main takeaway.
Caveats
The "about 10%" figure is approximate; some sources use different denominators and report lower estimates.
Not every drug in the listed classes depends on CYP2C19 to the same extent; the claim is about representative examples, not all members equally.
CYP2C19's clinical relevance often reflects both metabolism and genetic variation, so drug response can vary substantially by patient genotype.