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HEALTH

The Claim

The human enzymes CYP2C18 and CYP2C9 contribute to metabolism and other physiological functions in the human body.

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The Short Version

The statement is broadly supported, but one enzyme is much better established than the other. CYP2C9 clearly has major roles in drug and endogenous metabolism and affects physiological pathways. CYP2C18 is a human CYP enzyme with evidence of metabolic activity, yet its specific substrates and functions remain less well defined, so the claim slightly overstates certainty for that enzyme.

Caveats

  • CYP2C9 is well characterized; CYP2C18 is not characterized to the same level, especially regarding specific human substrates.
  • Some support for CYP2C18 relies on secondary summaries and family-level CYP descriptions rather than equally strong enzyme-specific human evidence.
  • 'Contribute to physiology' is broad language; for CYP2C18, the evidence is more consistent with possible or limited roles than with a fully mapped physiological function.

The Receipts

  1. CYP2C9 gene

    MedlinePlus Genetics

  2. CYP2C18 cytochrome P450 family 2 subfamily C member 18 [ (human)]

    NCBI Gene

  3. Biochemistry and molecular biology of the human CYP2C subfamily

    PubMed

  4. Substrates, inducers, inhibitors and structure-activity relationships of human CYP2C9

    University of Texas Southwestern Medical Center

  5. CYP2C9: an enzyme of major importance in human drug metabolism

    PMC

  6. Impact of genetic and non-genetic factors on hepatic CYP2C9

    Nature

  7. Massively parallel characterization of CYP2C9 variant enzyme activity

    Cell (American Journal of Human Genetics)

  8. Cytochrome P450 2C9 (CYP2C9)

    NIH (PMC)

  9. Cytochrome P450 2C9 (CYP2C9)

    St. Jude Research

  10. Cytochrome P450 Enzymes and Drug Metabolism in Humans

    MDPI

+ 16 more sources — see the full list on Lenz

Filed Under

CYP2C18CYP2C9

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