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Caenorhabditis elegans SID-2 is required for intestinal uptake of ingested double-stranded RNA.

The Claim

Caenorhabditis elegans SID-2 is required for intestinal uptake of ingested double-stranded RNA.

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The Short Version

SID-2 is required for intestinal uptake of ingested double-stranded RNA in Caenorhabditis elegans. Genetic studies show that animals lacking SID-2 resist RNA interference from ingested dsRNA but remain sensitive to injected dsRNA. Subsequent uptake experiments directly support SID-2’s role in importing ingested dsRNA into intestinal cells.

Caveats

  • Imaging alone does not fully distinguish initial uptake from intracellular accumulation; the conclusion also relies on genetic and functional experiments.
  • SID-2-dependent uptake has substrate-length and pH requirements, including selectivity for dsRNA of at least 50 base pairs.
  • Several listed sources are alternate records or copies of the same studies, not independent confirmations.

The Receipts

  1. Evolution of Susceptibility to Ingested Double-Stranded RNAs in Caenorhabditis Nematodes | PLOS One

    journals.plos.org

  2. Caenorhabditis elegans SID-2 is required for environmental RNA interference

    pnas.org

  3. Caenorhabditis elegans SID-2 is required for environmental RNA interference | PNAS

    pnas.org

  4. Distinct pathways for export of silencing RNA in Caenorhabditis elegans systemic RNAi: iScience

    cell.com

  5. Evolution of Susceptibility to Ingested Double-Stranded

    journals.plos.org

  6. Uptake of extracellular double-stranded RNA by SID-2

    pmc.ncbi.nlm.nih.gov

  7. SID-4/NCK-1 is important for dsRNA import in Caenorhabditis elegans

    pmc.ncbi.nlm.nih.gov

  8. Caenorhabditis elegans SID-2 is required for environmental RNA interference

    pmc.ncbi.nlm.nih.gov

  9. Uptake of extracellular double-stranded RNA by SID-2

    ncbi.nlm.nih.gov

  10. Evolution of susceptibility to ingested double-stranded ...

    pubmed.ncbi.nlm.nih.gov

+ 17 more sources — see the full list on Lenz

Filed Under

Caenorhabditis ElegansSID-2

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