The Short Version
No credible scientific source identifies protein paired with fruit as "the optimal macronutrient pairing for human metabolic function." While evidence confirms that adding protein to carbohydrate-containing meals can moderate short-term blood sugar spikes, this narrow benefit does not establish a single pairing as universally optimal. The highest-authority peer-reviewed sources explicitly state that ideal macronutrient balance remains debated and multiple dietary compositions support metabolic health.